Romeo Mesisca was born in Rome in 1944. In 1957, during renovation work at his parents' home, at the age of just 13 he first became acquainted with painting, copying a self-portrait by Matisse, using wallpaper paints as colours and a jute canvas fixed by his father onto an improvised wooden stretcher. In 1965, Mesisca began his career by taking part in the artistic events held on the steps of Trinità dei Monti and in the Galleria Colonna (now Galleria Alberto Sordi) in spring and autumn, coming into contact with the artists of the famous group "I ragazzi di Piazza del Popolo", including Mario Schifano, Tano Festa, Giosetta Fioroni and others who were very active in Rome at the time in the quadrilateral of Piazza di Spagna–Piazza del Popolo–Via Margutta–Piazza Navona. In 1968, after completing his secondary education, during his stay in Mantua for military service he frequented the Mantegna museum for over a year, where he had the opportunity to deepen his knowledge and carry out a detailed study of the great painter. In the 1970s, exhibiting in the halls of the Galleria Nazionale d'Arte Moderna in Rome, he began to have his first direct contacts with important figures and famous artists from Rome's cultural world. In 1971 he married Rossana Gavazza and their only son Stefano was born. In 1972 he began his teaching career, which did not prevent him from devoting himself to painting, exhibiting alongside Fiume, Fischer, Attardi, Guttuso, Calabria and Purificato. In 1973 he held his first solo exhibition at the Galleria d'Arte "Il Pendolo" in Rome and took part in various group shows alongside Fiume, Pievanini, Isola, Attardi, Calabria and Monachesi. In the same year, participating in the 3rd Biennale di Monterotondo (Rome), he had the chance to meet the writer Leonida Repaci, founder of the literary prize "Il Viareggio", who awarded him a commemorative plaque for painting. In 1974, for the 1974/1975 edition, the "Ars Dictandi" foundation awarded him the Campidoglio d'Oro from the City of Rome. His association with painters Alberto Sughi, Remo Brindisi and others strengthened his passion and artistic commitment to painting. In 1976 he joined the political trade union movement and met Renato Guttuso, senator of the P.C.I., who would have a decisive influence on his artistic future. In 1977 he met the art dealer A. Bellisi, owner of art galleries in Abidjan (Ivory Coast) and Paris, who offered him a one-year exhibition collaboration. In 1980 he was invited by Diana Gripenberg, granddaughter of the Scandinavian poet Bertel Gripenberg, founder and curator of the artistic movement "ZULEIKA". In 1981 he joined the Radio Giornale group of painters, exhibiting monthly in the former Galleria Colonna alongside some painters from the "Ragazzi di Piazza del Popolo" group. In 1982 he met Dario Ruffino, owner of the Galleria d'Arte "La Parametro" on Via Margutta, who marketed his works and presented them at the first television sales alongside Remo Brindisi, Ezio Farinelli, Bruno Landi, Aldo Pievanini and Lino Tardia. In 1983 he met Rossana Coglitore, owner of the Galleria d'Arte "Derna" in Rome, where he began a long-standing artistic collaboration. From 1984 to 1987 he took part in numerous exhibitions and solo shows in various Italian cities including Ferrara, Milan, Pesaro, Naples, Rome and Cosenza. In 1988 he was invited to exhibit, on the initiative of the UIL Confederale, in the halls of the Stenditoio di S. Michele in Rome for the exhibition "Art Against AIDS". In 1990 he moved to the northern part of Rome (Colli d'Oro), to the studio left by the painter Pasquale Monaco, gradually transforming it into an "art workshop" open to the public, passing on his technical knowledge of drawing and painting. In 1994 he participated by invitation in the art biennial "THE 2nd Sapporo International Print" in Sapporo (Japan). In 1996 he was invited by the Galleria d'arte "La Sfinge" in Rome, directed by Mauro Borgiani, for a solo exhibition on the occasion of the publication of his monograph by "Bor Art" of Rome. In 1997 he was appointed representative of Italian artists on the "Commissione Regionale del Lazio" for "Legge 200", alongside the art historian Prof. Giuseppe Appella and Prof. Claudio Strinati, superintendent of Cultural Heritage of Lazio. In 2001, invited by the Municipality of Tuscania, he held a solo exhibition in the former Temple of S. Croce on the occasion of the centenary celebrations of the birth of Giuseppe Cesetti. In 2005 he was invited to represent Italy with an exhibition at the "5th Edition" of the "Biennale Internazionale dell'Arte Contemporanea" in Florence. In 2009 he signed an exclusive contract with the company I-LXY of Bologna, directed by Monica Zanichelli, for one year of marketing in 16 countries in the Far East. In 2012 he was invited to participate in the international initiative "Artisti e Capre" conceived by Vittorio Sgarbi in Pesaro. In 2016 he received the 1st Prize for Painting with a "Gold Medal" at the "Apollo Dionisiaco" Award from the International Academy of Poetic Signification and Contemporary Art in Rome. In 2017 he was awarded an Honorary Degree from the International Academy of the Dioscuri with the citation "For having contributed to the successful dissemination of art culture in Italy and abroad". In 2020 he moved to Ariccia (Rome) with his studio in Genzano di Roma on the famous street where the Infiorata has been inaugurated every year since 1778. In 2023, the "ACCORSI ARTE" Art Gallery of Turin and Venice, directed by Dr. Daniela Accorsi, offered him a permanent collaboration. In 2024, invited by the Municipality of Apice (Benevento), he held a solo exhibition in the halls of the former Town Hall of Apice Vecchio during the Christmas festivities at the Castello dell'Ettore. On commission from the Basilica of Santa Maria degli Angeli in Pietrelcina (Benevento), he executed a large painting depicting San Pio (Padre Pio) with young people.